New ArrivalPrice Drops
Pros
- A Registered Trial, Not Just Ingredient Studies: Semaine ran its menopause formula through a registered clinical study, NCT05617287, across 42 women over 12 weeks.
- Verified Reviews At Volume: Junip records 4.52 stars across 2,505 independently verified buyer reviews, with 94% of reviewers recommending the brand.
- Ninety Days To Decide: First-time buyers can claim a full refund on up to two bottles within 90 days, and nothing needs to be posted back.
Cons
- Supplement facts panels are published as images rather than text and the gummy uses a proprietary blend, so ask support for exact dosages if you're comparing formulas side by side.
- The guarantee covers a first order up to two bottles, so treat the first purchase as the trial and settle on a format before moving to a subscription.
The Verdict
What sets Semaine apart is a cycle-support brand that put its own finished formulas through a registered trial rather than pointing at ingredient research: Semaine Health was founded in March 2020 by twin sisters Lauren Lee and Catherine Lee with bioengineer Matthew Crane, PhD, and works out of Atlanta, Georgia. The range covers the PMS Relief Capsule and PMS Relief Gummy, Hormone Balance, Peri/Meno Essentials, Stress Less Gummy, a Pre+Probiotic for Women with a travel version, and a Urinary Tract Cleanse & Protect, alongside multi-product protocols and a 40+ line for menopause. Hormone Balance publishes its full panel in text: per two-capsule serving it carries 20mg each of thiamine and B6, 680mcg DFE of L-5-MTHF folate, 4mcg of methylcobalamin, 19mg of magnesium, 20mg of zinc glycinate, 250mg of berberine phytosome, 180mg of grape seed extract and 80mg of passionflower, at 30 servings a container. A named medical advisory group includes Dr Michael Lewis, an OBGYN, Dr Barbara Chubak, a urologist, and Dr Jackie Crowell, a physical therapist. Prices open at $14.99 for the Pre+Probiotic travel blister and run to $32.99 for the PMS Relief Capsule and the full-size probiotic, $33.99 for the PMS Relief and Stress Less gummies, and $36.99 for Hormone Balance and Peri/Meno Essentials. Protocols and bundles run from $59.99 for the Bladder Resilience Protocol to $99.99 for 40+ Total and $175.99 for the Women's Wellness Bundle. Subscriptions are advertised at 15% off with free shipping, cancel at any time with no minimum term, and are managed through the account area without contacting support. The reservations are about what a buyer can check. The registered study is single-arm and open-label at 42 participants with self-reported outcomes, which is the weakest design for symptoms that respond strongly to placebo, and nothing has been peer-reviewed; Semaine states those limitations plainly for Hormone Balance, which is more than most brands do. The PMS page advertises 92% reporting less bloating where the testing lab's own published page for that product shows 71%, a gap worth asking about. The FDA disclaimer appears sitewide, but no address or phone number does, and the guarantee is written as 90 days in the refund policy while one product page advertises 60. Buy one format first, keep the receipt, and Semaine is one of the few brands in this aisle that has tested its own product at all.
Cycle, Hormone and Menopause Supplements
Semaine Health was founded in March 2020 by Lauren Lee, who serves as chief executive, her twin sister Catherine Lee, who heads operations, and Matthew Crane, PhD, a bioengineer who heads formulation. The company operates from Atlanta, Georgia, with arbitration under its terms seated there; no street address or telephone number is published on the site, and support runs by email at [email protected] from 9am to 5pm Eastern on weekdays. Fulfilment is handled by third-party logistics provider ShipBob. The domain has been registered since March 2019.
Current prices are $14.99 for the Pre+Probiotic Travel Blister, $32.99 for the PMS Relief Capsule and the Pre+Probiotic For Women, $33.99 for the PMS Relief Gummy and the Stress Less Gummy, $36.99 for Hormone Balance and Peri/Meno Essentials, $59.99 for the Bladder Resilience Protocol, $64.99 for the Microbiome Protocol, Daily Defense, 40+ Protection and 40+ Gut Balance, $69.99 for the Hormone Protocol, $84.99 for Perfect Cycle, $99.99 for 40+ Total and $175.99 for the Women's Wellness Bundle. Subscriptions are advertised at 15% off with free shipping; two and three-pack options are offered on most single products.
Hormone Balance publishes its full supplement facts panel in text: a two-capsule serving, 30 servings per container, carrying vitamin B1 20mg, vitamin B6 20mg, folate as L-5-MTHF 680mcg DFE, vitamin B12 as methylcobalamin 4mcg, magnesium 19mg, zinc as glycinate 20mg, berberine phytosome 250mg, grape seed extract 180mg and passionflower extract 80mg. The PMS Relief Capsule and Gummy and Peri/Meno Essentials publish their panels as images rather than text, and the gummy's actives sit inside a proprietary blend branded Sereinetrol, so per-ingredient amounts are not stated for those products. Products carry third-party tested, hormone-free, vegan, gluten-free, soy-free and non-GMO badges; no GMP, NSF or Informed Sport certification is claimed and no certificate of analysis is published.
Semaine registered a clinical study for its menopause formula, NCT05617287, sponsored by the company: an interventional single-group open-label study of 42 participants running 3 September 2022 to 1 January 2023, with self-reported change on a modified Menopause Rating Scale over 12 weeks as the primary outcome. Hormone Balance results come from a two-month observational open-label study of 45 women conducted by Citrus Labs and funded by Semaine, which the brand describes on the product page as not a randomised placebo-controlled trial and based on participant-reported outcomes rather than hormone measurements. The FDA disclaimer appears sitewide in the footer. Orders are packaged and shipped within one business day and typically arrive in four to six days; orders cannot be cancelled once placed, and a replacement or refund for a non-arriving order is requested 15 days after shipping. Returns run 90 days from the original shipping date, with a full refund on up to two bottles for first-time customers who are unsatisfied; the company accepts no physical returns and does not restock opened or unopened product, so nothing is posted back, and shipping is not refundable. One product page advertises a 60-day guarantee against the refund policy's 90. Subscriptions cancel through the account area with no penalty and no minimum order count. Junip, which states that all buyers are independently verified, records 4.52 stars across 2,505 reviews with 94% recommending; Trustpilot carries a single review on a profile claimed in August 2023.
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About this review
How this was written, who paid for what, and how the verdict stays independent.
Is this Semaine Health review sponsored?
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